Hi ExCAsurfer, thanks for your question! You're right, there is the potential for Hep B reactivation with some of the newer medications. However, many of these medications have extremely high cure rates for Hep C. It totally makes sense why this can be such a difficult decision, and you are so not alone. Making the decision to treat involves weighing all pros and cons, including the Hep B reactivation risk. Your doctor will be able to help determine this risk for you based on your specific situation and past medical history. I would recommend talking with your doctor or health care team to see what they think. Please keep us posted on everything! We're wishing you the best! -Casey, HepatitisC.net Team