"Almost through the first week of Epclusa. Feeling tired, low appetite, headaches mostly in the evening and morning, some night sweats, clenching of jaw, sore joints and muscles,light nausea,disrupted sleep, sore throat. however, many syptoms were occuring pre-treatment. Wondering if anyone else who has been treated with Epclusa may have had clenching of the jaw ? For now, the treatment is not too challenging. Yet, the last year of living with Hepatitis C has been really hard. I was treated previously in 2002 with Rebatron, I'm so grateful this new treatment is not like the old ones !!! I'm new to this site and hope everyone here is doing good today. "